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![]() ![]() The major function of NA is to remove sialic acid residues that are present on newly synthesised virions and the membrane of infected cells. The hemagglutinin (HA) and neuraminidase (NA) glycoproteins are the main targets of the humoral immune response raised after natural infection or vaccination, whereas NA is a target of the main antiviral drugs licensed for the treatment of human influenza infection. Influenza A and B viruses are major causes of respiratory tract infections in humans. Monitoring antiviral drug resistance in viruses and developing molecular methods for early diagnosis are considered to be of a priority level similar to that of the development of methods to detect bacterial strains with antimicrobial resistance. We also discuss the advantage of using an RT-ddPCR instead of qPCR method in the context of viral diagnostics and surveillance. Furthermore, reverse genetics viruses carrying this mutation were created to test the performance of the RT-ddPCR assay and compare it to the standard phenotypic NA assay. In this study, based on an existing reverse transcriptase real-time PCR (RT-qPCR) assay, we developed a reverse transcriptase droplet digital PCR assay (RT-ddPCR) to detect and quantify the frequency of the E119V-NA mutation. Once a mutation such as E119V-NA is known, highly sensitive PCR-based genotypic assays can be used to identify the prevalence of such mutant influenza viruses in clinical samples. The neuraminidase inhibition assay allows the phenotypical identification of resistant strains however, this test often has limited sensitivity with high variability depending on the virus strain, drugs and assays. Early detection of resistant influenza viruses is important for patient management and for the rapid containment of antiviral resistance. Naturally occurring oseltamivir-resistant seasonal H3N2 influenza virus strains often carry a glutamate-to-valine substitution at position 119 in the neuraminidase (E119V-NA). ![]() The monitoring of antiviral-resistant influenza virus strains is important for public health given the availability and use of neuraminidase inhibitors and other antivirals to treat infected patients. ![]() ![]() ![]() Youtube-dl is a popular program and is available in the default repositories of most Linux distributions, if not all. It’s up to you if you choose to download videos. Allows to bypass YouTube geo-restrictionsĭownloading videos from websites could be against their policies. ![]() Automatical pause and resume of video downloads.If the video is available in 4K, you can download it in 4K, 1080p, 720p etc You can also choose the quality of the video being downloaded.Allows downloading videos in several available video formats such as MP4, WebM etc.Download videos from not only YouTube but other popular video websites like Dailymotion, Facebook etc. ![]() This tiny tool has so many features that it won’t be an exaggeration to call it the best YouTube downloader for Linux. Which means you don’t need download managers in Linux just for resuming downloads. It will automatically resume the unfinished download, as long as a partial download is present in the current directory. If youtube-dl is killed (for example by Ctrl-C or due to loss of Internet connectivity) in the middle of the download, you can simply re-run it with the same YouTube video URL. The youtube-dl tool supports resuming interrupted downloads. It is written in pygtk and requires Python interpreter to run this program, it’s not platform restricted. It should run on any Unix, Windows or in Mac OS X based systems. Youtube-dl is a Python-based command-line tool that allows downloading videos from YouTube, Dailymotion, Photobucket, Facebook, Yahoo, Metacafe, Depositfiles and few more similar sites. Install youtube-dl to download YouTube videos in Linux terminal In this tutorial, I am going to show the steps for using youtube-dl for downloading videos from YouTube and other websites. But when it comes to Linux, nothing beats youtube-dl. There are various ways to download YouTube videos. With this tool, you can also choose video format and video quality such as 1080p or 4K. Brief: Easily download YouTube videos in Linux using youtube-dl command line tool. ![]() ![]() ![]() ![]() Working with direct materials suppliers, logistics and services providers, asset operators, and maintenance contractors, you can gain unparalleled supply chain visibility, agility, and resiliency. Now, with access to more solutions and services from SAP, businesses that have long benefited from the power and reach of Ariba Network can go further to facilitate collaboration with even more trading partners. Suppliers can help buyers achieve their procurement transformation goals, collaborating in the cloud to boost customer satisfaction, simplify the sales cycle, and improve cash flow.Buyers can automate the entire procurement process from source to settle, while controlling spending, finding new sources of savings, and building a healthy, ethical supply chain.SAP Business Network, formerly known to millions of companies around the world as Ariba Network, makes it straightforward for buyers and suppliers to collaborate on transactions, strengthen their relationships, and discover new business opportunities. ![]() ![]() ![]() The chart below breaks down the key differences between Dashlane’s and 1Password’s basic plans for business users.ĭashlane Business plan admins get access to an advanced reporting dashboard that helps with monitoring and enhancing security for employees’ password vaults. You can get a custom quote on an Enterprise plan directly through 1Password. ![]() Business customers have three options with 1Password: the Teams Starter Pack, Business and Enterprise.ġPassword’s Enterprise plans are tailored to your specific organizational needs. Dashlane has two business options: the Team and the Business plan. When it comes to business plans, there are several differences between Dashlane and 1Password. Overall, for personal and family plans, we feel 1Password has the edge over Dashlane due to considerably lower prices. **Add additional users for $1 per month each. *Prices shown here are per month but billed annually month-to-month billing is available for an extra fee. The chart below provides a glimpse at how Dashlane vs. When it comes to personal plans, 1Password is considerably less expensive. Still, that’s better than 1Password, which doesn’t offer a free plan. The main downside to Dashlane’s free plan is that you can only use your account on one device. Dashlane has a 30-day trial for non-business plans and a 14-day trial for business plans, and 1Password offers a 14-day trial for all its plans.ĭashlane’s free plan allows you to store up to 50 passwords and comes with basic features, including the password generator, personalized security alerts and form and payment autofill. ![]() Pricing and Plansīoth Dashlane and 1Password offer paid personal, family and business plans. While Dashlane and 1Password appear to be somewhat equally matched, a closer look at the features and costs at the plan level reveals key differences between the two solutions. 30 days for personal plans and 14 days for business plans ![]() ![]() Navigate to "HKLM\SOFTWARE\Microsoft\Windows\CurrentVersion\Uninstall\ " to verify that its display name is "WinZip" in the right pane. Click the Start button, type "regedit" into the search box and press "Enter." Click "Yes" or enter your password, if prompted. Use the Windows Registry Editor if WinZip appears in the list of installed programs in the Control Panel but you cannot uninstall it there. Right-click the folder and press "Delete." Click "Yes" to confirm that you want to delete the folder and its contents. Navigate to the WinZip program folder, but do not open it. Type ""%ProgramFiles%\WinZip\winzip32" /uninstall" (omit the quotes) into the Command Prompt window and press "Enter." Confirm that you want to uninstall the program, then close the Command Prompt window and restart your computer. Right-click "cmd.exe" and select "Run as Administrator." Click "Yes" or enter your password, if prompted. Right-click anywhere on the selected files and choose "Properties." Click the "Read Only" check box to clear it, then click "OK." Click "OK" on the Confirm Attribute Changes dialog box, then click "Continue" on the Access Denied prompt window.Ĭlick the Start button and type "cmd" in the search box. Press "Ctrl-A" to select all of the data in the folder. ![]() Click the Start button and select "Computer." Double-click your primary drive, which is usually C:, then double-click "Program Files." Double-click "WinZip" to open the program's folder. Open the WinZip program folder, which is saved in the "Program Files" folder by default. ![]() ![]() ![]() The software offers a range of customizable options, allowing users to create a workspace that suits their specific needs. Intuitive User InterfaceĬamtasia Studio 9’s user interface is intuitive and easy to navigate, making it ideal for beginners and professionals alike. They can also choose to upload their videos directly to popular video hosting sites, such as YouTube, Vimeo, and, or share them via email, social media, or other platforms. ![]() Users can export videos in a range of formats, including MP4, WMV, MOV, and AVI. Once the video is complete, Camtasia Studio 9 makes it easy to share the finished product. It also includes an extensive library of pre-built assets, such as callouts, lower thirds, and transitions, that can be easily added to videos. The software offers a range of features, including adding text, images, animations, and more, allowing users to create engaging and interactive videos. ![]() Once the screen recording is complete, users can take advantage of Camtasia Studio 9’s powerful editing tools. It also allows users to pause and resume recording, making it easy to create seamless recordings without any interruptions. The software offers a range of recording options, such as recording the entire screen, specific windows, or even specific applications. With just a few clicks, users can start recording their computer screen, including audio and webcam footage. One of the most significant features of Camtasia Studio 9 is its screen recording capabilities. ![]() In this article, we will take a closer look at some of the key features of Camtasia Studio 9 and explore why it is such a popular choice for video creation. It is an all-in-one solution that allows users to capture their computer screen and create high-quality videos with ease. Camtasia Studio 9: An All-In-One Screen Recording and Video Editing SolutionĬamtasia Studio 9 is a powerful screen recording and video editing software that is widely used by professionals and beginners alike. ![]() ![]() ![]() OS: Windows®XP SP3, Windows Vista/7/8 with latest service packs and updates installed.Explore iconic locations in Middle-earth, from the Shire to Goblin-town and beyond.Combine the Dwarves unique abilities to solve puzzles – often with hilarious results!.Battle ravenous Trolls, dangerous Orcs, and many more!.If we return then we will not be the same as before. The journey will take you through a wildland, treacherous lands. We go on a grandiose campaign, the purpose of which is to recapture the lost kingdom of the dwarfs from the dragon. No, the hole was a hobby, which means it was comfortable. Not in some disgusting, dirty, damp burrow, where the tails of worms stick out from all sides and smell disgustingly of mold, but also not in a dry sandy bare hole, where there is nothing to sit on and nothing to eat. Players will utilize and combine the Dwarves’ unique abilities – often with hilarious results – to solve the most diverse Quests of any LEGO videogame to date.There lived a hobbit in a hole underground. ![]() Along the way, he is introduced to ravenous Trolls, dangerous Orcs and, of course, Gollum and his precious Ring. Bilbo leaves the comforts of the Shire on a journey through Middle-earth to help the Dwarves reclaim their lost Kingdom of Erebor within the Lonely Mountain. The interactive game of LEGO The Hobbit allows gamers to play along their favorite scenes from the films and follows the Hobbit Bilbo Baggins as he is recruited by the Wizard Gandalf to aid Thorin Oakenshield and his Company of Dwarves. Graphics: NVIDIA GeForce 7600 GS or ATI Radeon X1950 Pro or betterįrom the makers of the immensely popular LEGO The Lord of the Rings, comes LEGO The Hobbit, inspired by the first two films in The Hobbit Trilogy: The Hobbit: An Unexpected Journey and the upcoming The Hobbit: Desolation of Smaug, productions of New Line Cinema and Metro-Goldwyn-Mayer Pictures (MGM) as well as the collection of LEGO The Hobbit constructions sets. Processor: AMD Athlon 64 X2 EE 3800+ (2*2000 Mhz) or similar Intel CPU, such as Intel Pentium Dual Core E2180 (2*2000 Mhz) OS: Windows®XP SP3, Windows Vista/7/8 with latest service packs and updates installed – Hosts : Mega, 1fichier, Uptobox, Uploaded, Turbobit – Language : English, French, Italian, German, Spanish, Danish, Dutch, Portuguese-Brazil, Russian, Polish ![]() ![]() For the Doctor the game presumably takes place between "A Good Man Goes To War" and "Let's Kill Hitler" or after the events of "The God Complex". The game takes place just before the events of " Silence in the Library/ Forest of the Dead" in River Song's timeline as indicated by various notes within her diary as well as the use of her title of 'Professor'. The game had previously been confirmed for release on 30 April 2012, but was later postponed to. ![]() Players will encounter Daleks, Cybermen, Silurians, and the Silence. Along the way is decision making which leads to "multiple possibilities" and puzzles. The plot is promised as allowing the player to take on the role of the Doctor and River Song as they travel across space and time in an effort to save Earth by gathering pieces of the eternity clock, an object that is a record of everything that has or will ever happen in all of existence. Similarly Alex Kingston returns to her role on the show as River Song. Matt Smith reprises his role as the Eleventh Doctor. It was released in digital stores by BBC Worldwide and in physical media in Europe for the PlayStation 3 and PlayStation Vita by Sony Computer Entertainment Europe. It was intended to be the first of a series, but it was announced in 2013 that the sequels have been put on hold. ![]() Microsoft Windows, PlayStation 3 ( PSN), PlayStation Vitaĭoctor Who: The Eternity Clock is a 2012 action-adventure video game based upon the BBC television series Doctor Who. Sony Computer Entertainment Europe (physical media) ![]() ![]() The turtles have access to a range of weapons such as nunchucks, bo staffs and throwing stars which can be used to defeat enemies. Each level contains enemies that must be defeated in order to progress. The game features a variety of different levels set in different locations such as sewers, rooftops and abandoned buildings. Players take control of one of the four turtles and use their unique fighting styles to battle enemies and progress through levels. The game follows four teenage mutant ninja turtles, Leonardo, Donatello, Raphael and Michelangelo, as they battle against the forces of evil in order to protect their home city of New York from the villainous Shredder and his Foot Clan. Teenage Mutant Ninja Turtles is a classic video game franchise that has been around since the 1980s. Teenage Mutant Ninja Turtles was released on 2003. ![]() Teenage Mutant Ninja Turtles ROM Free Download in direct link. ![]() |
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